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.. Pakeezah (1973) on IMDb: Movies, TV, Celebs, and more. Full Cast & Crew, Plot Summary, Awards, Trivia.

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Watch Pakeezah Movie online on a wide range of devices for free.. “Kurkuri Aur Milne Ki Pyaar”;.Identification of an amide-sulfone-amide scaffold in an MOPr antagonist series: a potent and orally efficacious antagonist of NMDA receptors.
NMDA receptor antagonists are associated with side effects that limit their therapeutic usefulness. Although many of these side effects involve the pore forming subunit GluN2A, the reasons for this are unknown. This study aimed at identification of receptor subunit-specific antagonists using MOPr and NMDA receptor-selective antagonists. All compounds bearing an amide-sulfone-amide scaffold identified in this study (designated as SPA/DA) inhibited NMDA receptor currents with a rank order of potency of R-SPA > SPA > DS > VPA. In contrast, those bearing either R- or S-SPA showed no activity. The potency of R-SPA was comparable to that of GluN2A preferring NR2B/D compounds, while the potency of S-SPA was similar to that of NR2B preferring compounds. In contrast to other NR2B preferring compounds, R-SPA potently inhibited MOPr function. Intrathecal (i.t.) administration of R-SPA produced an antinociceptive effect in a mouse formalin assay. More importantly, when orally administered, R-SPA produced a dose-dependent antinociception in the

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